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What should clinicians know about the renal effect and the mechanism of action of levosimendan?

作者信息

Honore Patrick M, Redant Sebastien, Moorthamers Sofie, Preseau Thierry, Kaefer Keitiane, Barreto Gutierrez Leonel, Attou Rachid, Gallerani Andrea, Boer Willem, De Bels David

机构信息

ICU Dept, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium.

Faculty of Medicine, ULB University, Bruxelle, Belgium.

出版信息

Expert Opin Drug Saf. 2021 Dec;20(12):1459-1461. doi: 10.1080/14740338.2021.1986483. Epub 2021 Oct 18.

DOI:10.1080/14740338.2021.1986483
PMID:34612116
Abstract
摘要

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What should clinicians know about the renal effect and the mechanism of action of levosimendan?
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Effects of levosimendan on glomerular filtration rate, renal blood flow, and renal oxygenation after cardiac surgery with cardiopulmonary bypass: a randomized placebo-controlled study.左西孟旦对体外循环心脏手术后肾小球滤过率、肾血流量和肾氧合的影响:一项随机安慰剂对照研究。
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Effect of Levosimendan on Renal Outcome in Cardiac Surgery Patients With Chronic Kidney Disease and Perioperative Cardiovascular Dysfunction: A Substudy of a Multicenter Randomized Trial.左西孟旦对合并慢性肾脏病及围手术期心血管功能障碍的心脏手术患者肾脏预后的影响:一项多中心随机试验的子研究
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引用本文的文献

1
Levosimendan: A New Therapeutical Strategy in Patients with Renal Insufficiency.左西孟旦:肾功能不全患者的一种新治疗策略。
Cardiovasc Drugs Ther. 2024 Aug 7. doi: 10.1007/s10557-024-07614-9.