Liu Xinwen, Lu Mengkai, Yu Yanna, Shen Nannan, Xia Haijiang, Shi Jiana, Fu Yongping, Hu Ying
Department of Pharmacy, the Affiliated Hospital of Shaoxing University, Shaoxing, 312000, PR China.
Department of Cardiovascular Medicine, the Affiliated Hospital of Shaoxing University, Shaoxing, 312000, PR China.
Cardiovasc Drugs Ther. 2024 Aug 7. doi: 10.1007/s10557-024-07614-9.
Levosimendan, a Ca2 + sensitizer with positive inotropic effects, is primarily employed for the short-term treatment of acute decompensated heart failure (ADHF). Levosimendan exerts renal function protection through various mechanisms, including anti-apoptosis, anti-inflammatory, and antioxidant effects in vivo. Additionally, levosimendan may have a protective effect on individuals with heart failure and renal insufficiency, as well as on renal function impairment after cardiac surgery. However, the application of levosimendan in patients with severe renal dysfunction remains controversial. This article delves into the use of levosimendan in severe renal insufficiency, explores its impact on renal function, and provides a comprehensive overview of its impact on renal function after cardiac surgery.
左西孟旦是一种具有正性肌力作用的钙离子增敏剂，主要用于急性失代偿性心力衰竭（ADHF）的短期治疗。左西孟旦通过多种机制发挥肾脏功能保护作用，包括体内的抗凋亡、抗炎和抗氧化作用。此外，左西孟旦可能对心力衰竭合并肾功能不全的个体以及心脏手术后的肾功能损害具有保护作用。然而，左西孟旦在严重肾功能不全患者中的应用仍存在争议。本文深入探讨了左西孟旦在严重肾功能不全中的应用，探讨其对肾功能的影响，并全面概述其对心脏手术后肾功能的影响。
