Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Complesso Universitario di Monserrato, S.S. 554, Bivio per Sestu, I-09042, Monserrato, Cagliari, Italy.
Dipartimento di Scienze della Vita e dell'Ambiente, Università degli Studi di Cagliari, Via Ospedale 72, 09124, Cagliari, Italy.
Org Biomol Chem. 2021 Oct 27;19(41):8912-8916. doi: 10.1039/d1ob01518d.
A novel Brønsted acid catalyzed tandem reaction provides highly functionalized cyclobuta-fused tetrahydroquinoline carboxylic esters from anilines and 2-alkylenecyclobutanones in good to high yield. During the reaction a dynamic diastereoselective cyclization is achieved, resulting in the formation of three contiguous stereocenters with high stereoselectivity.
一种新型的布朗斯特酸催化串联反应，可从苯胺和 2-亚烷基环丁酮中高产率得到高官能化的环丁并稠合四氢喹啉羧酸酯。在反应过程中，实现了动态的非对映选择性环化，高立体选择性地形成三个连续的立体中心。
