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上睑成形术(去除或不去除眼轮匝肌)对泪膜动力学和干眼症状的影响:一项随机对照试验。

Impact of upper blepharoplasty, with or without orbicularis oculi muscle removal, on tear film dynamics and dry eye symptoms: A randomized controlled trial.

机构信息

Department of Oral and Maxillofacial Surgery, University of Groningen and University Medical Center Groningen (UMCG), RB Groningen, The Netherlands.

Department of Ophthalmology, University of Groningen and University Medical Center Groningen (UMCG), RB Groningen, The Netherlands.

出版信息

Acta Ophthalmol. 2022 Aug;100(5):564-571. doi: 10.1111/aos.15036. Epub 2021 Oct 6.

Abstract

PURPOSE

Upper blepharoplasty may be related to dry eye symptoms since the function of the orbicularis oculi muscle may affect the tear film. We aimed to assess the effect of blepharoplasty with or without the removal of a strip of orbicularis oculi muscle on tear film dynamics and dry eye symptoms.

METHODS

A double-blind, randomized, controlled trial comparing upper blepharoplasty without (group A) or with (group B) orbicularis oculi muscle excision was performed on 54 healthy Caucasian patients. Tear film dynamics and dry eye symptoms were evaluated using multiple dry eye parameters, i.e. tear osmolarity, Schirmer test I, corneal/conjunctival staining, tear break-up time (TBUT), Oxford Scheme, Sicca Ocular Staining Score and Ocular Surface Disease Index questionnaire. All the parameters were assessed preoperatively and 6 and 12 months after upper blepharoplasty. All the groups' outcomes were compared.

RESULTS

The differences were not significant between the two upper blepharoplasty techniques regarding most of the above-mentioned outcomes. Subjective symptoms of ocular irritation, consistent with dry eye disease and vision-related impairment, were reduced after upper blepharoplasty independent of the type of the technique applied, while the pre and postoperative outcomes of the objective tear dynamics did not differ 12 months after surgery. However, group B demonstrated a significant increase in tear osmolarity and TBUT at the 6-month follow-up visit.

CONCLUSION

An upper blepharoplasty alleviates subjective dry eye complaints in the long term, while not changing the tear dynamics. The improvement was independent of the blepharoplasty technique used.

摘要

目的

上睑成形术可能与干眼症症状有关,因为眼轮匝肌的功能可能会影响泪膜。我们旨在评估行或不行眼轮匝肌切除术的上睑成形术对上眼睑成形术对泪膜动力学和干眼症症状的影响。

方法

一项双盲、随机、对照试验比较了 54 例健康白种人患者行单纯上睑成形术(A 组)或联合行眼轮匝肌切除术(B 组)的效果。使用多种干眼症参数评估泪膜动力学和干眼症症状,即泪液渗透压、Schirmer 试验 I、角膜/结膜染色、泪膜破裂时间(TBUT)、牛津方案、Sicca 眼染色评分和眼表面疾病指数问卷。所有参数在术前以及上睑成形术后 6 个月和 12 个月进行评估。比较所有组的结果。

结果

两种上睑成形术技术之间在上述大部分结果方面差异无统计学意义。与干眼症和视力相关损害一致的眼部刺激主观症状在上睑成形术后减轻,与所应用的技术类型无关,而术后 12 个月的客观泪液动力学的术前和术后结果没有差异。然而,B 组在 6 个月随访时泪液渗透压和 TBUT 显著增加。

结论

上睑成形术可长期缓解干眼症的主观症状,而不会改变泪液动力学。这种改善与所使用的上睑成形术技术无关。

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