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Regulation of self-renewal and senescence in primitive mesenchymal stem cells by Wnt and TGFβ signaling.Wnt 和 TGFβ 信号通路对原始间充质干细胞自我更新和衰老的调控。
Stem Cell Res Ther. 2023 Oct 26;14(1):305. doi: 10.1186/s13287-023-03533-y.
2
Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard.氮芥诱导角膜病变的研究进展—在氮芥暴露的小鼠模型中观察角膜各层的特异性改变
Exp Eye Res. 2023 Nov;236:109657. doi: 10.1016/j.exer.2023.109657. Epub 2023 Sep 16.
3
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases.间充质干细胞条件培养基/分泌组作为眼部疾病治疗选择的潜力。
Regen Med. 2023 Oct;18(10):795-807. doi: 10.2217/rme-2023-0089. Epub 2023 Sep 13.
4
Optimizing Acellular Dermal Matrix Integration in Heterologous Breast Reconstructive Surgery: Surgical Tips and Post-Operative Management.优化脱细胞真皮基质在异种乳房重建手术中的整合：手术技巧和术后管理。
Medicina (Kaunas). 2023 Jun 30;59(7):1231. doi: 10.3390/medicina59071231.
5
Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications.纳米脂肪在整形重建、再生及美容外科中的应用：面部聚焦应用进展综述
J Clin Med. 2023 Jun 28;12(13):4351. doi: 10.3390/jcm12134351.
6
Advances in the applications of mesenchymal stem cell-conditioned medium in ocular diseases.间充质干细胞条件培养基在眼部疾病中的应用进展。
Exp Eye Res. 2023 Aug;233:109560. doi: 10.1016/j.exer.2023.109560. Epub 2023 Jun 28.
7
Enhanced adipose-derived stem cells with IGF-1-modified mRNA promote wound healing following corneal injury.IGF-1 修饰 mRNA 增强的脂肪源性干细胞促进角膜损伤后的伤口愈合。
Mol Ther. 2023 Aug 2;31(8):2454-2471. doi: 10.1016/j.ymthe.2023.05.002. Epub 2023 May 10.
8
Clinical and Histopathological Study of the Effect of Adipose-Derived Mesenchymal Stem Cells on Corneal Neovascularization following Alkali Burn in a Rabbit Model.脂肪来源间充质干细胞对兔碱性烧伤后角膜新生血管化影响的临床和组织病理学研究。
Arch Razi Inst. 2022 Oct 31;77(5):1715-1721. doi: 10.22092/ARI.2022.357998.2136. eCollection 2022 Oct.
9
Inflammation and Dry Eye-like Symptoms as Concomitant Manifestations of Laryngo-Pharyngeal Reflux.炎症和干眼样症状作为喉咽反流的伴随表现。
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10
TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface.TFOS 生活方式报告：环境条件对眼表的影响。
Ocul Surf. 2023 Jul;29:1-52. doi: 10.1016/j.jtos.2023.04.007. Epub 2023 Apr 14.

释放多功能潜力：脂肪来源的间充质干细胞在眼表重建和眼部整形中的应用

Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics.

作者信息

Surico Pier Luigi, Scarabosio Anna, Miotti Giovanni, Grando Martina, Salati Carlo, Parodi Pier Camillo, Spadea Leopoldo, Zeppieri Marco

机构信息

Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, United States.

Department of Ophthalmology, Campus Bio-Medico University, Rome 00128, Italy.

出版信息

World J Stem Cells. 2024 Feb 26;16(2):89-101. doi: 10.4252/wjsc.v16.i2.89.

DOI:10.4252/wjsc.v16.i2.89
PMID:38455097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10915950/
Abstract

This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enhancement, demands advanced solutions for tissue restoration, functional and aesthetic refinement, and aging. Investigating immunomodulatory, regenerative, and healing capacities of MSCs, this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside, addressing common unmet needs in the field of reconstructive and regenerative surgery.

摘要

本综述全面探讨了间充质干细胞（MSCs）的多种潜力，特别关注脂肪来源的间充质干细胞。眼科和眼整形手术涵盖了各种用于眼部和眼周改善的手术，需要先进的组织修复、功能和美学优化以及抗老化解决方案。本综述研究了间充质干细胞的免疫调节、再生和愈合能力，强调了脂肪来源的间充质干细胞作为一种从实验室到临床的经济高效替代方案的潜在用途，以满足重建和再生手术领域常见的未满足需求。