释放多功能潜力：脂肪来源的间充质干细胞在眼表重建和眼部整形中的应用
Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics.
作者信息
Surico Pier Luigi, Scarabosio Anna, Miotti Giovanni, Grando Martina, Salati Carlo, Parodi Pier Camillo, Spadea Leopoldo, Zeppieri Marco
机构信息
Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, United States.
Department of Ophthalmology, Campus Bio-Medico University, Rome 00128, Italy.
出版信息
World J Stem Cells. 2024 Feb 26;16(2):89-101. doi: 10.4252/wjsc.v16.i2.89.
Abstract
This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enhancement, demands advanced solutions for tissue restoration, functional and aesthetic refinement, and aging. Investigating immunomodulatory, regenerative, and healing capacities of MSCs, this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside, addressing common unmet needs in the field of reconstructive and regenerative surgery.
摘要
本综述全面探讨了间充质干细胞（MSCs）的多种潜力，特别关注脂肪来源的间充质干细胞。眼科和眼整形手术涵盖了各种用于眼部和眼周改善的手术，需要先进的组织修复、功能和美学优化以及抗老化解决方案。本综述研究了间充质干细胞的免疫调节、再生和愈合能力，强调了脂肪来源的间充质干细胞作为一种从实验室到临床的经济高效替代方案的潜在用途，以满足重建和再生手术领域常见的未满足需求。
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2
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Exp Eye Res. 2023 Nov;236:109657. doi: 10.1016/j.exer.2023.109657. Epub 2023 Sep 16.
3
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Regen Med. 2023 Oct;18(10):795-807. doi: 10.2217/rme-2023-0089. Epub 2023 Sep 13.
4
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Medicina (Kaunas). 2023 Jun 30;59(7):1231. doi: 10.3390/medicina59071231.
5
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J Clin Med. 2023 Jun 28;12(13):4351. doi: 10.3390/jcm12134351.
6
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Exp Eye Res. 2023 Aug;233:109560. doi: 10.1016/j.exer.2023.109560. Epub 2023 Jun 28.
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