Chemistry & Industrial Hygiene, Inc., Wheat Ridge, Colorado, USA.
Department of Geology, Department of Geology, University of Maryland, College Park, MD, USA.
Inhal Toxicol. 2021 May-Jul;33(6-8):244-259. doi: 10.1080/08958378.2021.1971340. Epub 2021 Oct 6.
Carcinogenic properties of particulates depend, among other factors, on dimensional characteristics that affect their ability to reach sensitive tissue, to be removed or retained, and to interact with the cells.
To model mesothelioma and lung cancer potency of amphibole particles based on their dimensional characteristics and mineral habit (asbestiform vs. nonasbestiform) utilizing epidemiological data and detailed size information.
The datasets from recently created depository of dimensional information of elongate mineral particles were used to correlate mesothelioma and lung cancer potency with the fraction of particles in a specific size range and the ratio of length and width in different powers. In addition, the cancer potency factors were estimated and compared for 30 asbestiform, 15 nonasbestiform, and 10 mixed datasets.
For particles longer than 5 µm, the highest correlation with mesothelioma potency was achieved for width <0.22 µm, and with lung cancer <0.28 µm. The statistical power of the correlation was observed to lose significance at a maximum width of 0.6-0.7 µm. Mesothelioma potency correlated with length in the power of 1.9 divided by width in the power of 2.97, lung cancer potency with length in the power of 0.4 divided by width in the power of 1.17. The predicted cancer potencies of asbestiform, nonasbestiform, and mixed categories were significantly different.
While additional studies in this direction are warranted, this paper should serve as an additional confirmation for the role of fiber dimensions in the carcinogenicity of amphibole elongate mineral particles (EMPs).
颗粒的致癌特性取决于许多因素，包括影响其到达敏感组织的能力、被清除或保留的能力以及与细胞相互作用的能力的尺寸特征。
利用流行病学数据和详细的尺寸信息，基于角闪石颗粒的尺寸特征和矿物习性（石棉状与非石棉状），对间皮瘤和肺癌的潜能进行建模。
使用最近创建的细长矿物颗粒尺寸信息存储库中的数据集，将间皮瘤和肺癌的潜能与特定尺寸范围内的颗粒分数以及不同幂次的长度与宽度之比相关联。此外，还针对 30 个石棉状、15 个非石棉状和 10 个混合数据集估计和比较了癌症潜能因子。
对于长度大于 5 µm 的颗粒，与间皮瘤潜能相关性最高的是宽度 <0.22 µm，与肺癌的相关性则是宽度 <0.28 µm。相关性的统计效力在最大宽度为 0.6-0.7 µm 时失去了显著意义。间皮瘤潜能与长度的 1.9 次方除以宽度的 2.97 次方相关，肺癌潜能与长度的 0.4 次方除以宽度的 1.17 次方相关。石棉状、非石棉状和混合类别预测的癌症潜能存在显著差异。
尽管在这方面还需要进一步的研究，但本文应作为角闪石细长矿物颗粒（EMP）致癌性中纤维尺寸作用的进一步确认。
