Department of Emergency, Yidu Central Hospital of Weifang, Weifang, Shandong, China.
Clinical Internal Medicine, Qingzhou Mihe Central Health Center, Shandong, Weifang, China.
Bioengineered. 2021 Dec;12(1):8614-8621. doi: 10.1080/21655979.2021.1988361.
Acute coronary syndrome (ACS) is a critical illness in cardiovascular disease. The purpose of this study was to investigate the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and D-dimer in predicting the occurrence of no reflow in emergency percutaneous coronary intervention (PCI) in patients with ACS. One hundred and sixty-eight ACS patients were recruited, including 88 patients with normal reflow and 80 patients with no reflow after emergency PCI. The levels of serum NT-proBNP and D-dimer in the patients were detected before PCI, immediately after PCI, 2 hours, and 6 months after PCI. The ROC curve was used to evaluate the predictive value of NT-proBNP and D-dimer in no-reflow phenomenon. Logistic regression model was used to analyze the independent influencing factors of no reflow phenomenon. Logistic regression analysis confirmed that NT-proBNP and D-dimer were independent predictors of the occurrence of no reflow in the total population. The ROC curve showed that the AUC value was 0.909 when NT-proBNP combined with D-dimer. The detection of NT-proBNP combined with D-dimer was helpful to predict the occurrence of no-reflow phenomenon after emergency PCI in ACS patients.
急性冠状动脉综合征（ACS）是心血管疾病中的一种危急病症。本研究旨在探讨 N 末端脑钠肽前体（NT-proBNP）和 D-二聚体在预测 ACS 患者急诊经皮冠状动脉介入治疗（PCI）中无复流发生的价值。纳入 168 例 ACS 患者，其中 88 例为再灌注正常，80 例为急诊 PCI 后无复流。检测患者 PCI 前、PCI 后即刻、2 小时和 6 个月时的血清 NT-proBNP 和 D-二聚体水平。采用 ROC 曲线评估 NT-proBNP 和 D-二聚体对无复流现象的预测价值。采用 logistic 回归模型分析无复流现象的独立影响因素。Logistic 回归分析证实，NT-proBNP 和 D-二聚体是总人群无复流发生的独立预测因素。ROC 曲线显示，当 NT-proBNP 联合 D-二聚体检测时，AUC 值为 0.909。检测 NT-proBNP 联合 D-二聚体有助于预测 ACS 患者急诊 PCI 后无复流现象的发生。
