Care Policy and Evaluation Centre, London School of Economics and Political Science, London, UK.
Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.
Int J Geriatr Psychiatry. 2022 Jan;37(1). doi: 10.1002/gps.5633. Epub 2021 Oct 15.
Cognitive stimulation therapy (CST) is one of the few non-pharmacological interventions for people living with dementia shown to be effective and cost-effective. What are the current and future cost and health-related quality of life implications of scaling-up CST to eligible new cases of dementia in England?
METHODS/DESIGN: Data from trials were combined with microsimulation and macrosimulation modelling to project future prevalence, needs and costs. Health and social costs, unpaid care costs and quality-adjusted life years (QALYs) were compared with and without scaling-up of CST and follow-on maintenance CST (MCST).
Scaling-up group CST requires year-on-year increases in expenditure (mainly on staff), but these would be partially offset by reductions in health and care costs. Unpaid care costs would increase. Scaling-up MCST would also require additional expenditure, but without generating savings elsewhere. There would be improvements in general cognitive functioning and health-related quality of life, summarised in terms of QALY gains. Cost per QALY for CST alone would increase from £12,596 in 2015 to £19,573 by 2040, which is below the threshold for cost-effectiveness used by the National Institute for Health and Care Excellence (NICE). Cost per QALY for CST and MCST combined would grow from £19,883 in 2015 to £30,906 by 2040, making it less likely to be recommended by NICE on cost-effectiveness grounds.
Scaling-up CST England for people with incident dementia can improve lives in an affordable, cost-effective manner. Adding MCST also improves health-related quality of life, but the economic evidence is less compelling.
认知刺激疗法(CST)是为数不多的对痴呆症患者有效的非药物干预措施之一,且具有成本效益。将 CST 扩展到英国新的符合条件的痴呆症患者中,对当前和未来的成本和健康相关生活质量会有什么影响?
方法/设计:将试验数据与微观模拟和宏观模拟模型相结合,预测未来的患病率、需求和成本。比较了扩展 CST 和后续维持性 CST(MCST)对健康和社会成本、无报酬护理成本以及质量调整生命年(QALY)的影响。
扩展 CST 组需要逐年增加支出(主要是人员支出),但这将部分被健康和护理成本的减少所抵消。无报酬护理成本将会增加。扩展 MCST 还需要额外的支出,但在其他方面没有节省。认知功能和健康相关生活质量总体上会有所改善,用 QALY 收益来概括。仅 CST 的成本效益比从 2015 年的 12596 英镑增加到 2040 年的 19573 英镑,低于英国国家卫生与临床优化研究所(NICE)使用的成本效益阈值。CST 和 MCST 联合使用的成本效益比从 2015 年的 19883 英镑增加到 2040 年的 30906 英镑,这使得 CST 更不可能因成本效益原因而被 NICE 推荐。
在英国,为新发痴呆症患者扩展 CST 可以以负担得起的、具有成本效益的方式改善生活。增加 MCST 也可以提高健康相关的生活质量,但经济证据的说服力较弱。