SSD Clinical Pharmacology, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.
Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy; Infectious Diseases Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.
Int J Antimicrob Agents. 2021 Nov;58(5):106445. doi: 10.1016/j.ijantimicag.2021.106445. Epub 2021 Oct 3.
Dalbavancin is increasingly used for the treatment of staphylococcal osteoarticular infections (OIs). Some population pharmacokinetic studies suggest that a regimen of two 1500 mg doses 1 week apart could ensure effective treatment for several weeks. Here we aim to provide clinicians with a proof-of-concept of the potential role that therapeutic drug monitoring may have in giving real-time feedback of the estimated duration of optimal treatment of staphylococcal OIs with dalbavancin in each single patient.
达巴万星越来越多地被用于治疗葡萄球菌性骨关节炎感染（OIs）。一些群体药代动力学研究表明，1 周内给予两次 1500mg 剂量的方案可以确保数周的有效治疗。在这里，我们旨在为临床医生提供一个概念验证，即治疗药物监测可能在为每个患者提供关于达巴万星治疗葡萄球菌性 OIs 的最佳治疗持续时间的实时反馈方面发挥作用。
