Huang Shujing, Sun Hongyan, Yu Jia, Shi Hongfei, Ren Liyun, He Yan, Zhang Mingzhi, Peng Hao, Guo Heng
Department of Public Health, School of Medicine, Shihezi University, Shihezi, People's Republic of China.
Center for Disease Prevention and Control of Tianning District, Changzhou, People's Republic of China.
Risk Manag Healthc Policy. 2021 Sep 29;14:4063-4072. doi: 10.2147/RMHP.S332098. eCollection 2021.
Sleep duration was associated with large artery atherosclerosis, but its association with atherosclerosis in lower extremity arteries was not well studied. Together with sleep, physical activity constitutes main component of our daily life and influences sleep. Here, we aimed to examine the independent and joint associations of sleep duration and physical activity with peripheral artery disease (PAD) in Chinese adults.
In Tianning cohort, night-time sleep duration and physical activity were assessed by the Pittsburgh Sleep Quality Index and the Global Physical Activity Questionnaire, respectively, for 5130 participants (51.0±15.6 years, 58.7% female). PAD was defined as ankle-brachial index (ABI) <0.9. General linear, and logistic regression models were used to assess the associations of sleep duration and physical activity with PAD. The biological interaction between sleep duration and physical activity on PAD was examined using additive model.
Compared to participants sleeping 6-8.9 h, those sleeping ≥9 h had a 0.02 lower ABI (β=-0.02, =0.007) and 38% higher odds of PAD (OR=1.38, =0.035). Compared to physically active participants sleeping 6-8.9 h, among ≥9 h group, physically inactive individuals had significantly increased odds of PAD (OR=2.40, <0.001), whereas physically active individuals did not (OR=1.15, =0.472). On additive scale, attributable proportion due to interaction (0.40, 95% CI: 0.07, 0.73) indicated a significant interaction between sleep duration and physical activity on PAD.
Being physically active may attenuate the detrimental association between prolonged sleep duration and PAD. Moreover, we found a significant interaction between prolonged sleep duration and physical inactivity in the prevalence of PAD.
睡眠时间与大动脉粥样硬化有关，但其与下肢动脉粥样硬化的关联尚未得到充分研究。身体活动与睡眠共同构成我们日常生活的主要组成部分，并影响睡眠。在此，我们旨在研究中国成年人睡眠时间和身体活动与外周动脉疾病（PAD）的独立及联合关联。
在天宁队列中，分别采用匹兹堡睡眠质量指数和全球身体活动问卷对5130名参与者（年龄51.0±15.6岁，女性占58.7%）的夜间睡眠时间和身体活动进行评估。PAD定义为踝臂指数（ABI）<0.9。使用一般线性模型和逻辑回归模型评估睡眠时间和身体活动与PAD的关联。采用相加模型检验睡眠时间和身体活动对PAD的生物学交互作用。
与睡眠时间为6 - 8.9小时的参与者相比，睡眠时间≥9小时的参与者ABI低0.02（β=-0.02，P=0.007），患PAD的几率高38%（OR=1.38，P=0.035）。与睡眠时间为6 - 8.9小时且身体活动的参与者相比，在睡眠时间≥9小时的组中，身体不活动的个体患PAD的几率显著增加（OR=2.40，P<0.001），而身体活动的个体则没有（OR=1.15，P=0.472）。在相加尺度上，交互作用的归因比例为0.40（95%CI：0.07，0.73），表明睡眠时间和身体活动对PAD存在显著交互作用。
身体活动可能会减弱睡眠时间延长与PAD之间的有害关联。此外，我们发现睡眠时间延长和身体不活动在PAD患病率方面存在显著交互作用。
