Shanghai National Clinical Research Centre for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China.
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Diabetes Metab. 2021 Mar;47(2):101174. doi: 10.1016/j.diabet.2020.07.001. Epub 2020 Jul 10.
The present study examined the associations between night-time sleep duration, midday napping duration and bedtime, and fasting glucose levels, and whether or not such associations are dependent on gender and age.
This study was a cross-sectional analysis of 172,901 adults aged≥40 years living in mainland China. Sleep duration was obtained by self-reports of bedtime at night, waking-up time the next morning and average napping duration at midday. Fasting plasma glucose (FPG)≥7.0mmol/L was defined as hyperglycaemia. Independent associations between night-time sleep duration, midday naptime duration and bedtime with hyperglycaemia were evaluated using regression models.
Compared with night-time sleep durations of 6-7.9h, both short (<6h) and long (≥8h) night-time sleep durations were significantly associated with an increased risk of hyperglycaemia in women [odds ratio (OR): 1.12, 95% confidence interval (CI): 1.01-1.29 and OR: 1.14, 95% CI: 1.08-1.21, respectively], and revealed a U-shaped distribution of risk in women and no significant association in men. Long midday nap durations (≥1h) were significantly but weakly associated with hyperglycaemia (OR: 1.04, 95% CI: 1.01-1.09) compared with no napping without interactions from gender or age, whereas the association between bedtime and fasting glucose levels did vary according to gender and age.
Night-time sleep duration, midday napping duration and bedtime were all independently associated with the risk of hyperglycaemia, and some of the associations between these sleep characteristics and hyperglycaemia were gender- and age-dependent.
本研究旨在探讨夜间睡眠时间、午睡时间和就寝时间与空腹血糖水平之间的关系，以及这些关系是否依赖于性别和年龄。
本研究是对居住在中国内地≥40 岁的 172901 名成年人进行的横断面分析。睡眠时间通过自我报告的夜间就寝时间、次日早晨醒来时间和平均午睡时间来获得。空腹血糖（FPG）≥7.0mmol/L 定义为高血糖。使用回归模型评估夜间睡眠时间、午睡时间和就寝时间与高血糖之间的独立关联。
与 6-7.9 小时的夜间睡眠时间相比，女性的短（<6 小时）和长（≥8 小时）夜间睡眠时间均与高血糖风险增加显著相关[比值比（OR）：1.12，95%置信区间（CI）：1.01-1.29 和 OR：1.14，95% CI：1.08-1.21]，且在女性中呈 U 形分布，而在男性中无显著相关性。与不午睡（无交互作用来自性别或年龄）相比，长午睡时间（≥1 小时）与高血糖显著相关（OR：1.04，95%CI：1.01-1.09），但与性别或年龄无关。然而，就寝时间与空腹血糖水平之间的关系因性别和年龄而异。
夜间睡眠时间、午睡时间和就寝时间均与高血糖风险独立相关，这些睡眠特征与高血糖之间的一些关系存在性别和年龄依赖性。
