Immune Tolerance Network, University of California San Francisco, San Francisco, CA, United States.
Immune Tolerance Network, Duke University, Durham, NC, United States.
Front Immunol. 2021 Sep 20;12:744804. doi: 10.3389/fimmu.2021.744804. eCollection 2021.
The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance.
理性的免疫耐受恢复方法的发展需要一种迭代方法，该方法建立在过去的成功基础上，并利用对免疫介导的病理的新机制见解。本文将回顾从免疫耐受网络临床试验经验中发展而来的概念，重点介绍这些试验中进行的创新性机制研究的经验教训，以及正在开发的诱导耐受的新策略。
