Islam Tarequl, Sagor Md Shahjalal, Tamanna Noshin Tabassum, Bappy Md Kamrul Islam, Haque Md Azizul, Lackner Maximilian
Department of Microbiology, Noakhali Science and Technology University, Noakhali 3814, Bangladesh.
Department of Microbiology, Jagannath University, Dhaka 1100, Bangladesh.
J Pers Med. 2025 Mar 14;15(3):112. doi: 10.3390/jpm15030112.
The appendix, an integral part of the large intestine, may serve two purposes. First of all, it is a concentration of lymphoid tissue that resembles Peyer's patches. It is also the main location in the body for the creation of immunoglobulin A (IgA), which is essential for controlling intestinal flora's density and quality. Second, the appendix constitutes a special place for commensal bacteria in the body because of its location and form. Inflammation of the appendix, brought on by a variety of infectious agents, including bacteria, viruses, or parasites, is known as appendicitis. According to a number of studies, the consequences of appendectomies may be more subtle, and may relate to the emergence of heart disease, inflammatory bowel disease (IBD), and Parkinson's disease (PD), among other unexpected illnesses. A poorer prognosis for recurrent infection is also predicted by the absence of an appendix. Appendectomies result in gut dysbiosis, which consequently causes different disease outcomes. In this review, we compared the compositional differences between the appendix and gut microbiome, the immunological role of appendix and appendix microbiome (AM), and discussed how appendectomy is linked to different disease consequences.
阑尾是大肠的一个组成部分，可能有两个作用。首先，它是一个类似于派尔集合淋巴结的淋巴组织集中区。它也是体内产生免疫球蛋白A（IgA）的主要部位，而IgA对于控制肠道菌群的密度和质量至关重要。其次，阑尾因其位置和形态，在体内是共生细菌的一个特殊场所。由包括细菌、病毒或寄生虫在内的多种感染因子引起的阑尾炎症被称为阑尾炎。根据多项研究，阑尾切除的后果可能更为微妙，可能与心脏病、炎症性肠病（IBD）和帕金森病（PD）等其他意想不到的疾病的出现有关。阑尾缺失还预示着反复感染的预后较差。阑尾切除术会导致肠道菌群失调，进而导致不同的疾病后果。在这篇综述中，我们比较了阑尾和肠道微生物群的组成差异、阑尾及阑尾微生物群（AM）的免疫作用，并讨论了阑尾切除术与不同疾病后果之间的联系。
