Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Oxid Med Cell Longev. 2021 Sep 25;2021:8457521. doi: 10.1155/2021/8457521. eCollection 2021.
Ferroptosis is a new type of regulatory cell death that differs from autophagy, apoptosis, necrosis, and pyroptosis; it is caused primarily by the accumulation of iron and lipid peroxides in the cell. Studies have shown that many classical signaling pathways and biological processes are involved in the process of ferroptosis. In recent years, investigations have revealed that ferroptosis plays a crucial role in the progression of tumors, especially lung cancer. In particular, inducing ferroptosis in cells can inhibit the growth of tumor cells, thereby reversing tumorigenesis. In this review, we summarize the characteristics of ferroptosis from its underlying basis and role in lung cancer and provide possible applications for it in lung cancer therapies.
铁死亡是一种新型的调控性细胞死亡方式，有别于自噬、细胞凋亡、细胞坏死和细胞焦亡；它主要是由细胞内铁和脂质过氧化物的积累引起的。研究表明，许多经典的信号通路和生物学过程都参与了铁死亡的过程。近年来的研究揭示，铁死亡在肿瘤的进展中起着关键作用，特别是在肺癌中。特别是，诱导细胞发生铁死亡可以抑制肿瘤细胞的生长，从而逆转肿瘤发生。在这篇综述中，我们总结了铁死亡的特点，从其基础和在肺癌中的作用，并为其在肺癌治疗中的可能应用提供了依据。
