类orosomucoid蛋白3、鼻病毒与哮喘
Orosomucoid-like protein 3, rhinovirus and asthma.
作者信息
Zhang You-Ming
机构信息
Section of Genomic and Environmental Medicine, National Heart and Lung Institute, Molecular Genetics Group, Division of Respiratory Sciences, Imperial College London, London SW3 6LY, United Kingdom.
出版信息
World J Crit Care Med. 2021 Sep 9;10(5):170-182. doi: 10.5492/wjccm.v10.i5.170.
Abstract
The genetic variants of orosomucoid-like protein 3 () gene are associated with highly significant increases in the number of human rhinovirus (HRV)-induced wheezing episodes in children. Recent investigations have been focused on the mechanisms of in rhinovirus infection for asthma and asthma exacerbations. not only regulates major human rhinovirus receptor intercellular adhesion molecule 1 expression, but also plays pivotal roles in viral infection through metabolisms of ceramide and sphingosine-1-phosphate, endoplasmic reticulum (ER) stress, ER-Golgi interface and glycolysis. Research on the roles of in HRV infection will lead us to identify new biomarkers and novel therapeutic targets in childhood asthma and viral induced asthma exacerbations.
摘要
类orosomucoid蛋白3（）基因的遗传变异与儿童人鼻病毒（HRV）诱发的喘息发作次数显著增加有关。最近的研究集中在该基因在鼻病毒感染导致哮喘和哮喘加重中的机制。该基因不仅调节主要的人鼻病毒受体细胞间粘附分子1的表达，还通过神经酰胺和1-磷酸鞘氨醇的代谢、内质网（ER）应激、内质网-高尔基体界面和糖酵解在病毒感染中发挥关键作用。对该基因在HRV感染中作用的研究将引导我们识别儿童哮喘和病毒诱发的哮喘加重中的新生物标志物和新治疗靶点。
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