Noureddine Nazek, Chalubinski Maciej, Wawrzyniak Paulina
Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Zurich, Switzerland.
Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
J Asthma Allergy. 2022 Apr 18;15:487-504. doi: 10.2147/JAA.S324080. eCollection 2022.
The respiratory epithelium constitutes the physical barrier between the human body and the environment, thus providing functional and immunological protection. It is often exposed to allergens, microbial substances, pathogens, pollutants, and environmental toxins, which lead to dysregulation of the epithelial barrier and result in the chronic inflammation seen in allergic diseases and asthma. This epithelial barrier dysfunction results from the disturbed tight junction formation, which are multi-protein subunits that promote cell-cell adhesion and barrier integrity. The increasing interest and evidence of the role of impaired epithelial barrier function in allergy and asthma highlight the need for innovative approaches that can provide new knowledge in this area. Here, we review and discuss the current role and mechanism of epithelial barrier dysfunction in developing allergic diseases and the effect of current allergy therapies on epithelial barrier restoration.
呼吸道上皮构成了人体与环境之间的物理屏障，从而提供功能和免疫保护。它经常暴露于过敏原、微生物物质、病原体、污染物和环境毒素中，这些会导致上皮屏障失调，并引发过敏性疾病和哮喘中所见的慢性炎症。这种上皮屏障功能障碍是由紧密连接形成紊乱导致的，紧密连接是促进细胞间黏附和屏障完整性的多蛋白亚基。上皮屏障功能受损在过敏和哮喘中的作用越来越受到关注且有越来越多证据，这凸显了对创新方法的需求，这些方法能够在该领域提供新知识。在此，我们回顾并讨论上皮屏障功能障碍在过敏性疾病发生中的当前作用和机制，以及当前过敏疗法对上皮屏障恢复的影响。
