Uziel A
Acta Otolaryngol Suppl. 1986;429:23-7. doi: 10.3109/00016488609122726.
Cochlear structures are sensitive to the morphogenetic effect of thyroid hormone during the whole duration of maturation. For each structure, there exists a period of maximal sensitivity to thyroid hormone which corresponds to the period of development during which the structure of interest undergoes its main morphological changes (6 to 13 days for the inner sulcus epithelium, 6 to 10 days for the pillars, the 2nd and a part of the 3rd postnatal week for OHCs and their efferent innervation in rats). These periods of sensitivity can be considered as critical periods because cochlear structures are maximally vulnerable to thyroid deficiency during these periods.
在整个成熟过程中，耳蜗结构对甲状腺激素的形态发生作用敏感。对于每个结构，都存在一个对甲状腺激素的最大敏感期，这与该结构经历其主要形态变化的发育时期相对应（内沟上皮为6至13天，支柱为6至10天，大鼠外毛细胞及其传出神经支配为出生后第2周和第3周的一部分）。这些敏感期可被视为关键时期，因为在这些时期耳蜗结构对甲状腺功能减退最为敏感。
