嗜酸性粒细胞性鼻息肉的特应性方面及嗜酸性粒细胞积聚的可能机制。

Atopic aspect of eosinophilic nasal polyposis and a possible mechanism of eosinophil accumulation.

作者信息

Ogawa H

出版信息

Acta Otolaryngol Suppl. 1986;430:12-7.

Abstract

Eosinophil-infiltrated nasal polyps (eosinophilic polyps) have been increasing in Japan. This increase is parallel with an increase in cases of nasal allergy, and is an interesting contrast to the decrease in chronic infectious nasal diseases. Thus IgE-mediated hypersensitivity could be considered an etiologic factor of eosinophilic polyposis. However only 29.7% of patients with eosinophilic polyposis were defined as being atopic. In this study, high levels of IgG-immune complex were found in eosinophilic polyp fluid. It is conceivable that the IgG-immune complex may play some part in tissue eosinophilia of polyps.

摘要

嗜酸性粒细胞浸润性鼻息肉（嗜酸性粒细胞性息肉）在日本的发病率一直在上升。这种上升与鼻过敏病例的增加同步，与慢性感染性鼻病的减少形成有趣的对比。因此，IgE介导的超敏反应可被视为嗜酸性粒细胞性息肉病的一个病因。然而，只有29.7%的嗜酸性粒细胞性息肉病患者被定义为特应性体质。在本研究中，在嗜酸性粒细胞性息肉液中发现了高水平的IgG免疫复合物。可以想象，IgG免疫复合物可能在息肉的组织嗜酸性粒细胞增多中起一定作用。