Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute-Antoni Van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Department of Clinical Pharmacy and Pharmacology, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands.
Support Care Cancer. 2022 Apr;30(4):2933-2943. doi: 10.1007/s00520-021-06605-y. Epub 2021 Oct 7.
Palliative cancer patients can benefit from deprescribing of potentially inappropriate medications (PIMs). Tools and guidelines developed for the geriatric population are mainly available. This systematic review gives an overview of available guidelines and tools to deprescribe for palliative cancer patients.
A systematic search was carried out using the databases SCOPUS and PubMed. Studies focused on palliative cancer patients were included.
The search identified 137 studies of which 15 studies were included in this systematic review. Six of the included tools were developed specifically for cancer patients. One of these tools was externally validated and applied in several studies and settings. Guidelines or tools that were not specifically developed for cancer patients but that were applied on cohorts of palliative cancer patients were also included.
Tools developed for geriatric patients contain drugs that are not inappropriate when used in the palliative cancer care setting. Tools developed for cancer patients are more suitable and can be applied in combination with stepwise methods to individualize deprescribing per patient. The tools and guidelines described in this systematic review can be used to further implement deprescribing in the clinical routine for palliative cancer patients.
姑息治疗癌症患者可从潜在不适当药物（PIMs）的减药中获益。主要提供了适用于老年人群的工具和指南。本系统评价概述了姑息治疗癌症患者减药可用的指南和工具。
使用 SCOPUS 和 PubMed 数据库进行系统检索。纳入关注姑息治疗癌症患者的研究。
搜索共确定了 137 项研究，其中 15 项研究纳入本系统评价。纳入的 15 项工具中有 6 项是专门为癌症患者开发的。其中一个工具经过外部验证，并在多项研究和环境中应用。还纳入了不是专门为癌症患者开发但应用于姑息治疗癌症患者队列的指南或工具。
为老年患者开发的工具中包含在姑息治疗癌症护理环境中使用时不适当的药物。为癌症患者开发的工具更适用，并且可以与逐步方法结合应用，以针对每个患者进行个体化减药。本系统评价中描述的工具和指南可用于进一步将减药纳入姑息治疗癌症患者的临床常规。
