Adl Alireza, Motamedifar Mohammad, Malekzadeh Parastoo, Sedigh-Shams Mahdi
Department of Endodontics, Biomaterials Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Microbiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Aust Endod J. 2022 Dec;48(3):386-391. doi: 10.1111/aej.12575. Epub 2021 Oct 7.
The purpose of this study was to evaluate the disinfection of dentinal tubules with diclofenac sodium (DS), N-acetylcysteine (NAC) and calcium hydroxide (CH). Contaminated dentinal blocks were divided into two control and seven experimental groups (n = 15): CH, DS, NAC, CH + 5% DS, 50% CH + 50% DS, CH + 5% NAC and 50% CH + 50% NAC. After seven days, dentine debris was obtained from two depths of 100 and 200 µm. The bacterial load was assessed by counting the number of colony-forming units (CFUs). Pure DS exhibited maximum antibacterial activity at both depths. At 200 µm, it showed statistically significant differences with all the other groups (P < 0.05). Mixing CH with either 5% or 50% of DS and NAC did not increase the antibacterial efficacy (P > 0.05). Pure DS was most effective in disinfecting dentinal tubules, and mixing CH with DS or NAC is not recommended.
本研究的目的是评估双氯芬酸钠（DS）、N-乙酰半胱氨酸（NAC）和氢氧化钙（CH）对牙本质小管的消毒效果。将受污染的牙本质块分为两个对照组和七个实验组（n = 15）：CH、DS、NAC、CH + 5% DS、50% CH + 50% DS、CH + 5% NAC和50% CH + 50% NAC。七天后，从100和200 µm的两个深度获取牙本质碎屑。通过计算菌落形成单位（CFU）的数量来评估细菌载量。纯DS在两个深度均表现出最大的抗菌活性。在200 µm处，它与所有其他组相比具有统计学显著差异（P < 0.05）。将CH与5%或50%的DS和NAC混合并未提高抗菌效果（P > 0.05）。纯DS在消毒牙本质小管方面最有效，不建议将CH与DS或NAC混合使用。
