Subiksha Kannan, Jena Amit, Sarangi Priyanka, Mohanty Saumyakanta, Sahoo Sajan, Mallick Rashmi Rekha
Department of Conservative Dentistry and Endodontics, SCB Dental College and Hospital, Cuttack, Odisha, India.
Department of Zoology, Ravenshaw University, Cuttack, Odisha, India.
J Conserv Dent Endod. 2024 Dec;27(12):1246-1250. doi: 10.4103/JCDE.JCDE_588_24. Epub 2024 Dec 10.
The main objective of root canal treatment is the removal of bacteria. Established medicaments and their combinations have been compromised in efficacy against , causing the need to explore novel intracanal medicaments.
The aim of the study was to evaluate the antibacterial efficacy of chitosan, -acetylcysteine (NAC), and as intracanal medicaments against biofilm.
Minimum inhibitory concentration and susceptibility of medicaments determined. Two hundred and forty dentin disc specimens were prepared and inoculated with for 21 days. Samples were divided into four groups (A - -acetylcysteine; B - ; C - Chitosan; D -Control) ( = 60), and two subgroups ( = 30) based on the duration of medicament placed (subgroup 1: 24 h, subgroup 2: 7 days). Thereafter, dentinal shavings were retrieved, incubated in agar plate, visible colonies counted, and statistically analyzed.
At 24 h Group C1 exhibited the lowest CFUs, followed by Group A1, Group B, and Group D1. On the 7 day, Group B2 showed the lowest CFUs, followed by Group A2, Group C2, and Group D2.
Against , NAC has the highest antimicrobial properties closely followed by and both provide promising novel possibilities for use as intracanal medicaments.
根管治疗的主要目标是清除细菌。已有的药物及其组合在对抗[细菌名称未给出]方面的疗效受到影响，这使得有必要探索新型根管内药物。
本研究的目的是评估壳聚糖、N - 乙酰半胱氨酸（NAC）和[药物名称未给出]作为根管内药物对[细菌名称未给出]生物膜的抗菌效果。
测定药物的最低抑菌浓度和敏感性。制备240个牙本质盘标本，接种[细菌名称未给出]21天。根据药物放置时间将样本分为四组（A - N - 乙酰半胱氨酸；B - [药物名称未给出]；C - 壳聚糖；D - 对照组）（每组n = 60），并进一步分为两个亚组（每组n = 30）（亚组1：24小时，亚组2：7天）。此后，收集牙本质碎屑，在琼脂平板上培养，计数可见菌落，并进行统计学分析。
在24小时时，C1组的菌落形成单位（CFU）最低，其次是A1组、B组和D1组。在第7天时，B2组的CFU最低，其次是A2组、C2组和D2组。
在对抗[细菌名称未给出]方面，NAC具有最高的抗菌性能，其次是[药物名称未给出]，两者都为作为根管内药物的使用提供了有前景的新可能性。
