Qi Zhenjie, Wang Shaozhong
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Org Lett. 2021 Nov 5;23(21):8549-8553. doi: 10.1021/acs.orglett.1c03252. Epub 2021 Oct 7.
Chemodivergent reactions of oximes and diazo esters involving Rh-catalyzed [3+2] annulation and photodriven O-H insertion have been developed to generate oxazoles and oxime ethers. A range of aldehyde and ketone oximes reacted with α-diazocarbonyl compounds in a controllable manner in which functional groups, including ketone, ester, amide, ether, thiol ether, silane, alkene, allene, and alkyne groups, were well tolerated.
已经开发出肟和重氮酯的化学发散反应，涉及铑催化的[3+2]环化反应和光驱动的O-H插入反应，以生成恶唑和肟醚。一系列醛肟和酮肟与α-重氮羰基化合物以可控方式反应，其中包括酮、酯、酰胺、醚、硫醚、硅烷、烯烃、丙二烯和炔烃基团在内的官能团都具有良好的耐受性。
