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α-羰基铑卡宾引发的重氮巴比妥酸酯与亚烷基吡唑啉酮的串联组装用于合成螺并呋喃嘧啶

α-Carbonyl Rh-Carbenoid Initiated Cascade Assembly of Diazobarbiturates with Alkylidene Pyrazolones for Synthesis of Spirofuropyrimidines.

作者信息

Zhang Yue, Mi Yu-Hang, Wang Kuo, Zhao Hong-Wu

机构信息

College of Life Science and Bio-Engineering, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing 100124, China.

出版信息

Molecules. 2024 Jul 3;29(13):3178. doi: 10.3390/molecules29133178.

DOI:10.3390/molecules29133178
PMID:38999130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11243257/
Abstract

Catalyzed by Rh(esp) (10 mol%) and (±)-BINAP (20 mol%) in DCE at 80 °C, the cascade assembly between diazobarbiturates and alkylidene pyrazolones proceeded readily and produced spiro-furopyrimidines in 38-96% chemical yields. The chemical structure of the prepared spirofuro-pyrimidines was firmly confirmed by X-ray diffraction analysis.

摘要

在80℃下于1,2-二氯乙烷中，以Rh(esp)（10摩尔%）和（±）-联萘酚磷酸酯（20摩尔%）为催化剂，重氮巴比妥酸盐与亚烷基吡唑啉酮之间的串联组装反应顺利进行，以38 - 96%的化学产率生成了螺环呋喃嘧啶。通过X射线衍射分析确定了所制备的螺环呋喃嘧啶的化学结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b21c/11243257/71f7a1037ede/molecules-29-03178-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b21c/11243257/9208dc065c3e/molecules-29-03178-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b21c/11243257/dc13595d3821/molecules-29-03178-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b21c/11243257/71f7a1037ede/molecules-29-03178-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b21c/11243257/9208dc065c3e/molecules-29-03178-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b21c/11243257/dc13595d3821/molecules-29-03178-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b21c/11243257/71f7a1037ede/molecules-29-03178-sch002.jpg

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