作为醌甲基化物前体的天然醌类——合理药物设计中的理念
Natural quinones as quinonemethide precursors--ideas in rational drug design.
作者信息
Moore H W, Czerniak R, Hamdan A
出版信息
Drugs Exp Clin Res. 1986;12(6-7):475-94.
PMID:3461932
Abstract
The concept of the mode of biological action of quinones as bioreductive alkylating agents is presented. The focus of this discussion is primarily upon the structural features which would facilitate quinonemethide formation (alkylating agent) from the reduced quinone (hydroquinone). A survey of the naturally occurring quinone field was carried out and those members which can be catalogued as potential bioreductive alkylating agents are listed.
摘要
本文提出了醌作为生物还原烷基化剂的生物作用模式的概念。本次讨论的重点主要是有助于从还原醌（对苯二酚）形成醌甲基化物（烷基化剂）的结构特征。对天然存在的醌领域进行了调查，并列出了那些可归类为潜在生物还原烷基化剂的成员。
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