T1801 A、B、C和D，由一株假单胞菌产生的新型醌类和对苯二酚类抗生素。

T1801 A, B, C, and D, new quinone and hydroquinone antibiotics produced by a strain of Pseudomonas.

作者信息

Kumagai K, Kato M, Nabeshima S, Tsuyumu S

机构信息

Biotechnology Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd., Hyogo, Japan.

出版信息

Biosci Biotechnol Biochem. 1992 Sep;56(9):1439-42. doi: 10.1271/bbb.56.1439.

DOI:10.1271/bbb.56.1439

PMID:1368951

Abstract

New antibiotics, T1801 A, B, C, and D, were isolated from the culture broth of Pseudomonas sp. SC-1801. Their structures were found by spectroscopic analyses to be tri- and tetra(methylthio) derivatives of hydroquinone (T1801 A and C) or p-benzoquinone (T1801 B and D). They are new quinone and hydroquinone antibiotics and are active against Gram-positive bacteria, some fungi, and yeasts.

摘要

新型抗生素T1801 A、B、C和D是从假单胞菌属SC - 1801的培养液中分离得到的。通过光谱分析发现它们的结构是对苯二酚（T1801 A和C）或对苯醌（T1801 B和D）的三（甲硫基）和四（甲硫基）衍生物。它们是新型醌类和对苯二酚类抗生素，对革兰氏阳性菌、一些真菌和酵母具有活性。