School of Teacher Education, Zhejiang Normal University, Jinhua, China; Key Laboratory of Intelligent Education Technology and Application of Zhejiang Province, Zhejiang Normal University, Jinhua, China.
Institute of Brain Science and Department of Psychology, School of Education, Hangzhou Normal University, Hangzhou, China.
J Affect Disord. 2022 Jan 1;296:233-240. doi: 10.1016/j.jad.2021.09.062. Epub 2021 Sep 25.
Recent resting-state functional magnetic resonance imaging studies have provided strong evidence of abnormal regional spontaneous brain activities among anxiety-disordered patients. However, the evidence has been divergent and inconclusive. Therefore, it is necessary to perform a meta-analysis identifying a common pattern of altered regional spontaneous brain activity for anxiety disorders.
Corresponding research of anxiety disorders, namely, whole-brain rs-fMRI studies that measured differences in regional homogeneity, amplitude of low-frequency fluctuations, or fractional amplitude of low-frequency fluctuations, were analyzed in this study. Overall, seven studies with 235 anxiety-disordered patients and 241 healthy controls were ultimately included in the meta-analysis. The meta-analysis was processed by seed-based d mapping.
Compared with healthy controls, patients with anxiety disorders showed significantly decreased regional spontaneous brain activities in the right putamen, the right orbital inferior frontal gyrus, and the right temporal pole. No increases in regional spontaneous brain activities were detected in patients relative to the controls.
Limited number of available studies, only Asian samples, and insufficient information of sample characteristics.
The present study suggests that anxiety disorders are associated with aberrant regional brain activity in areas connected with emotion processing, which extends our understanding of anxiety disorders' pathophysiology.
最近的静息态功能磁共振成像研究为焦虑障碍患者的异常区域自发性脑活动提供了有力证据。然而，证据存在分歧，尚无定论。因此，有必要进行荟萃分析，以确定焦虑障碍的区域自发性脑活动的常见模式。
该研究分析了焦虑障碍的全脑 rs-fMRI 研究，这些研究测量了区域同质性、低频波动幅度或低频波动分数幅度的差异。最终纳入了 7 项研究，共 235 名焦虑障碍患者和 241 名健康对照者。荟萃分析采用种子点 d 映射法进行处理。
与健康对照组相比，焦虑障碍患者右侧壳核、右侧眶额下回和右侧颞极的区域自发性脑活动明显降低。与对照组相比，患者的区域自发性脑活动没有增加。
可用研究数量有限，仅为亚洲样本，样本特征信息不足。
本研究表明，焦虑障碍与情绪处理相关区域的异常脑活动有关，这扩展了我们对焦虑障碍病理生理学的理解。
