苦枥木提取物的提取、纯化及放射性碘标记作为癌症治疗诊断试剂。
Extraction, purification and radioiodination of Khellin as cancer theranostic agent.
机构信息
Labeled Compounds Department, Hot Laboratories Centre, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt; Radioisotopes Production Facility, Second Egyptian Research Reactor Complex, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt.
Radioactive Isotopes and Generator Department, Hot Laboratories Centre, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt.
出版信息
Appl Radiat Isot. 2021 Dec;178:109970. doi: 10.1016/j.apradiso.2021.109970. Epub 2021 Oct 2.
Khellin was successfully extracted from Ammi visnaga fruits with a recovery percent of 96.15%. Next radio-iodination of Khellin was successfully achieved with a high yield. The biodistribution study of [I]iodo-khellin in tumour bearing mice revealed that khellin preferentially localization at tumour tissue. Target prediction study for [I]iodo-khellin revealed that PI3K and VEGFR are potential targets for iodo-khellin with good affinity. The results of this study potentiate [I]iodo-khellin as a good theranostic agent for tumour imaging and therapy.
从孜然芹果实中成功提取了海廉，回收率为 96.15%。接下来，海廉的放射性碘标记也成功实现，产率很高。[I]碘海廉在荷瘤小鼠中的生物分布研究表明，海廉优先定位于肿瘤组织。[I]碘海廉的靶标预测研究表明，PI3K 和 VEGFR 是碘海廉的潜在靶标，具有良好的亲和力。这项研究的结果表明，[I]碘海廉是一种用于肿瘤成像和治疗的良好治疗诊断试剂。
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