Huang N W, Qiao X H, Li L J
Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2021 Oct 9;56(10):1045-1049. doi: 10.3760/cma.j.cn112144-20210320-00131.
Mitochondria, as the main site of cell metabolism and energy generation, contains the genome encoding the respiratory chain-associated complexes. Deletions or mutations of mitochondria will lead to mitochondrial respiratory chain deficiencies and these deficiencies play an important role in metabolic reprogramming which is considered as one of the important features of tumorigenesis and development. Many studies have found that tunneling nanotube (TNT), a well-established mitochondrial transfer pathway, is able to restore mitochondrial respiratory deficiencies. This review article focuses on the occurrence of mitochondrial transfer, the mechanism of TNT formation and the promising therapeutic targets acting on mitochondrial transfer.
线粒体作为细胞代谢和能量产生的主要场所，包含编码呼吸链相关复合物的基因组。线粒体的缺失或突变会导致线粒体呼吸链缺陷，而这些缺陷在代谢重编程中起重要作用，代谢重编程被认为是肿瘤发生和发展的重要特征之一。许多研究发现，隧道纳米管（TNT）是一种公认的线粒体转移途径，能够恢复线粒体呼吸缺陷。这篇综述文章重点关注线粒体转移的发生、TNT形成的机制以及作用于线粒体转移的有前景的治疗靶点。
