NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Department of Histology and Embryology, School of Basic Medicine Sciences, Central South University, Changsha, Hunan Province, 410013, China.
J Exp Clin Cancer Res. 2024 May 21;43(1):147. doi: 10.1186/s13046-024-03069-w.
A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during the process of tumorigenesis, even in the presence of abundant oxygen, shifting the main pathway of energy metabolism from the tricarboxylic acid cycle to aerobic glycolysis. Recent studies have unveiled the dynamic transfer of mitochondria within the tumor microenvironment, not only between tumor cells but also between tumor cells and stromal cells, immune cells, and others. In this review, we explore the pathways and mechanisms of mitochondrial transfer within the tumor microenvironment, as well as how these transfer activities promote tumor aggressiveness, chemotherapy resistance, and immune evasion. Further, we discuss the research progress and potential clinical significance targeting these phenomena. We also highlight the therapeutic potential of targeting intercellular mitochondrial transfer as a future anti-cancer strategy and enhancing cell-mediated immunotherapy.
一个世纪前，Warburg 效应首次被提出，揭示了癌细胞在肿瘤发生过程中主要依赖糖酵解，即使在有丰富氧气的情况下，也会将能量代谢的主要途径从三羧酸循环转移到有氧糖酵解。最近的研究揭示了线粒体在肿瘤微环境中的动态转移，不仅在肿瘤细胞之间，而且在肿瘤细胞与基质细胞、免疫细胞等之间。在这篇综述中，我们探讨了肿瘤微环境中线粒体转移的途径和机制，以及这些转移活动如何促进肿瘤侵袭性、化疗耐药性和免疫逃逸。此外，我们还讨论了针对这些现象的研究进展和潜在的临床意义。我们还强调了靶向细胞间线粒体转移作为未来抗癌策略的治疗潜力，并增强细胞介导的免疫治疗。
