Jiang Y W, Zhang Y B, Pan A
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Sep 6;55(9):1159-1167. doi: 10.3760/cma.j.cn112150-20210729-00726.
Using Meta-analysis to evaluate the relation of sugar-sweetened beverages (SSBs) intakes and artificially sweetened beverages (ASBs) intakes with risk of incident cardiovascular disease. "Sugar-sweetened beverages"(SSBs),"artificially sweetened beverages"(ASBs),"coronary heart disease"(CHD),"stroke","cardiovascular disease"(CVD), and related terms (both in English and in Chinese) were searched in Pubmed, EMBASE, Web of Science, Cochrane library, ProQuest, China National Knowledge Infrastructure (CNKI), Wanfang databases, and VIP Chinese Science and Technology Journal. Besides, it searched for additional references in websites including Clinical Tirals.gov and International Clinical Trials Registry Platform. The time was up to May 31st 2020. Stata 13 software was used to calculate pooled , perform heterogeneity test, and assess publication bias. A total of 14 articles were included from the 40 804 articles retrieved, including 12 articles from European and American countries and 2 articles from Asian countries. The baseline mean age of the participants ranged from 52 to 69 years, and the mean follow-up time was from 6 to 26 years. Meta-analysis showed that compared with those in the lowest group, the (95%) for those in the highest group of SSBs consumption was 1.11 (1.04-1.08) for CHD, 1.10 (1.01-1.19) for stroke, and 1.09 (0.96-1.24) for CVD events. The corresponding (95%) comparing extreme groups of ASBs consumption was 1.10 (0.98-1.23) for CHD, 1.19 (1.09-1.29) for stroke, and 1.32 (1.15-1.52) for CVD events. Further analysis for subtypes of stroke showed that compared with the lowest group, the (95%) for those in the highest groups of SSBs consumption was 1.10 (0.99-1.22) for ischemic stroke and 0.86 (0.71-1.04) for hemorrhagic stroke. The corresponding (95%) comparing extreme consumption of ASBs was 1.23 (1.04-1.46) for ischemic stroke and 1.33 (1.03-1.72) for hemorrhagic stroke. Higher consumption of SSBs or ASBs may lead to increased risk of incident CHD and stroke (particularly ischemic stroke).
使用荟萃分析评估含糖饮料（SSB）摄入量和人工甜味饮料（ASB）摄入量与心血管疾病发病风险之间的关系。在PubMed、EMBASE、科学网、考克兰图书馆、ProQuest、中国知网、万方数据库和维普中文科技期刊数据库中检索了“含糖饮料”（SSB）、“人工甜味饮料”（ASB）、“冠心病”（CHD）、“中风”、“心血管疾病”（CVD）以及相关术语（中英文）。此外，还在Clinical Tirals.gov和国际临床试验注册平台等网站上搜索了其他参考文献。检索时间截至2020年5月31日。使用Stata 13软件计算合并效应量、进行异质性检验并评估发表偏倚。从检索到的40804篇文章中，共纳入14篇文章，其中12篇来自欧美国家，2篇来自亚洲国家。参与者的基线平均年龄在52至69岁之间，平均随访时间为6至26年。荟萃分析表明，与最低组相比，SSB消费最高组患冠心病的风险比（95%置信区间）为1.11（1.04 - 1.08），中风为1.10（1.01 - 1.19），心血管疾病事件为1.09（0.96 - 1.24）。ASB消费极端组对比的相应风险比（95%置信区间），冠心病为1.10（0.98 - 1.23），中风为1.19（1.09 - 1.29），心血管疾病事件为1.32（1.15 - 1.52）。对中风亚型的进一步分析表明，与最低组相比，SSB消费最高组患缺血性中风的风险比（95%置信区间）为1.10（0.99 - 1.22），出血性中风为0.86（0.71 - 1.04）。ASB极端消费对比的相应风险比（95%置信区间），缺血性中风为1.23（1.04 - 1.46），出血性中风为1.33（1.03 - 1.72）。较高的SSB或ASB消费量可能会导致冠心病和中风（尤其是缺血性中风）发病风险增加。
