Kim Youngyo, Je Youjin
Department of Food and Nutrition, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, 130-701 Seoul, South Korea.
Department of Food and Nutrition, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, 130-701 Seoul, South Korea.
Arch Cardiovasc Dis. 2016 Apr;109(4):242-53. doi: 10.1016/j.acvd.2015.10.005. Epub 2016 Jan 19.
Several observational studies have suggested that high consumption of sugar-sweetened beverages (SSBs) and artificially sweetened beverages (ASBs) is associated with increased blood pressure, but this relationship has not been investigated comprehensively.
To quantitatively examine the association between sugar-sweetened and artificially sweetened beverage intake and risk of hypertension.
We performed a systematic review and meta-analysis of eligible prospective cohort studies, identified by searching PubMed, Embase and Web of Science databases up to May 2015. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model, and generalized least-squares trend estimation was used to assess dose-response relationships.
Six studies (246,822 subjects and 80,628 incident cases of hypertension) were identified for the meta-analysis of SSBs and hypertension. The pooled RR of hypertension in the highest category of SSB consumption (≥1 serving/day, mean) compared with the lowest category of SSB (<0.6 serving/month, mean) was 1.12 (95% CI: 1.07, 1.17). In a dose-response analysis, a 1 serving/day increase in SSB intake was associated with an 8% increased risk of hypertension (RR: 1.08, 95% CI: 1.06, 1.11). Four studies (227,254 subjects and 78,177 incident cases of hypertension) were included in the meta-analysis of ASBs and hypertension. The pooled RRs were 1.14 (95% CI: 1.10, 1.18) for highest versus lowest analysis and 1.09 (95% CI: 1.06, 1.11) for every additional 1 serving/day increase in ASB consumption. The positive association did not vary significantly by sex, duration of follow-up or adjustment for body mass index.
Our findings indicate that high SSB and ASB consumption is associated with an increased risk of hypertension.
多项观察性研究表明，高糖饮料（SSB）和人工甜味饮料（ASB）的高摄入量与血压升高有关，但这种关系尚未得到全面研究。
定量研究含糖饮料和人工甜味饮料的摄入量与高血压风险之间的关联。
我们对符合条件的前瞻性队列研究进行了系统评价和荟萃分析，通过检索截至2015年5月的PubMed、Embase和Web of Science数据库来确定这些研究。使用随机效应模型计算合并相对风险（RR）及95%置信区间（CI），并采用广义最小二乘趋势估计来评估剂量反应关系。
六项研究（246,822名受试者和80,628例高血压发病病例）被纳入SSB与高血压的荟萃分析。与最低SSB摄入量组（平均每月<0.6份）相比，最高SSB摄入量组（平均每天≥1份）高血压的合并RR为1.12（95%CI：1.07, 1.17）。在剂量反应分析中，SSB摄入量每天增加1份与高血压风险增加8%相关（RR：1.08，95%CI：1.06, 1.11）。四项研究（227,254名受试者和78,177例高血压发病病例）被纳入ASB与高血压的荟萃分析。最高与最低分析的合并RR为1.14（95%CI：1.10, 1.18），ASB摄入量每增加1份/天，合并RR为1.09（95%CI：1.06, 1.11）。这种正相关在性别、随访时间或体重指数调整方面没有显著差异。
我们的研究结果表明，高SSB和ASB摄入量与高血压风险增加有关。
