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孟德尔随机化在眼科及其他医学领域的应用

[Application of Mendelian randomization in ophthalmology and other medical fields].

作者信息

Kang Y T, Li S M

机构信息

Beijing Tongren Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100730, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2021 Oct 11;57(10):791-795. doi: 10.3760/cma.j.cn112142-20210302-00102.

Abstract

In recent years, the application of Mendelian randomization has become more and more widely in the world. By taking genes as instrumental variables, it can eliminate the interference of confounding factors and reverse causality in the system, and effectively judge the causal correlation between exposure factors and outcomes, which has a unique advantage for etiological exploration in the medical field. This article reviews the application of Mendelian randomization in ophthalmology and provides new ideas for the development of correlational and causal studies in Ophthalmology. .

摘要

近年来,孟德尔随机化在全球的应用越来越广泛。通过将基因作为工具变量,它可以消除系统中混杂因素和反向因果关系的干扰,并有效判断暴露因素与结局之间的因果关联,这在医学领域病因探索方面具有独特优势。本文综述了孟德尔随机化在眼科中的应用,并为眼科相关和因果研究的发展提供新思路。

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