Department of Pharmacology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia;, Email:
Department of Pharmacology, University of Zagreb, School of Medicine, Zagreb, Croatia.
Pharmazie. 2021 Oct 1;76(10):519-521. doi: 10.1691/ph.2021.1114.
The discovery of bacterial viruses able to kill bacteria, named bacteriophages (phages), more than a century ago, contributed to combating bacterial infections during the first three decades of the 20th century. Vladimir Sertić, a Croatian microbiologist, was one of the pioneers in bacteriophages investigation, who performed significant scientific research on phage strains characterization, isolation, and classification. The important contribution of Vladimir Sertić can be seen from his private archive (from the 1930s) which contains hundreds of valuable archival materials that are today kept at the Department of Pharmacology School of Medicine, Zagreb. The Discovery of this archive was recently described by Lackovic and Toljan. Here we describe a further survey of this archive. In addition to many documents, it contains phage cocktails in a small commercial paper box, with instructions for usage, as clear evidence of their therapeutic application in the pre-antibiotic era. This revelation, not shown in the literature up to now, to the best of our knowledge, motivated us to present it to the wider scientific and professional community with this short article, giving an additional brief overview of the current perspective of phage investigation and therapeutic application.
一个多世纪前，人们发现了能够杀死细菌的细菌病毒，即噬菌体（phages），这一发现为 20 世纪头 30 年的细菌感染防治做出了贡献。克罗地亚微生物学家弗拉基米尔·塞蒂奇（Vladimir Sertić）是噬菌体研究的先驱之一，他在噬菌体株的特性、分离和分类方面进行了重要的科学研究。从他的私人档案（20 世纪 30 年代）中可以看出弗拉基米尔·塞蒂奇的重要贡献，这些档案中有数百份有价值的档案材料，现藏于萨格勒布医科大学药理学系。拉科维奇和托尔扬最近描述了这个档案的发现。在这里，我们进一步调查了这个档案。除了许多文件外，它还包含一小盒商业用纸包装的噬菌体鸡尾酒，附有使用说明，这清楚地证明了它们在抗生素前时代的治疗应用。据我们所知，这一发现以前在文献中没有显示出来，这促使我们用这篇短文向更广泛的科学界和专业界介绍这一发现，并简要概述当前噬菌体研究和治疗应用的观点。
