Department of Genetics and Genome Biology, University of Leicester, University Road, LE1 7RH, UK.
Department of Genetics and Genome Biology, University of Leicester, University Road, LE1 7RH, UK.
Curr Opin Biotechnol. 2021 Apr;68:310-317. doi: 10.1016/j.copbio.2021.03.002. Epub 2021 Apr 13.
Bacteriophages (phages) are natural biological entities that kill bacteria with species specific precision, rendering them attractive for therapeutic purposes. Phages were discovered over a century ago, but, after antibiotic discovery, their use as antimicrobials dwindled. Interest in phage therapy has, however, been rekindled by increasing multi-drug resistance to routine and frontline antibiotics and by the slowing of antibiotic innovations. To build on fundamental phage research studies and compassionate usage, information on safety and efficacy of phages is needed to motivate clinical trials and are necessary for phage therapy to become mainstream. In this review, we discussed essential phage characterisation parameters alongside the merits and limitations of state-of-the-art models to gather preclinical data on the safety and efficacy of phage therapeutics.
噬菌体（phages）是一种能够精准杀死特定细菌的天然生物实体，因此在治疗方面具有很大的吸引力。噬菌体早在一个多世纪前就已被发现，但在抗生素被发现后，它们作为抗菌药物的用途逐渐减少。然而，由于常规和一线抗生素的耐药性不断增加，以及抗生素创新速度放缓，人们对噬菌体疗法的兴趣又重新燃起。为了在基础噬菌体研究和同情使用的基础上更进一步，需要获得有关噬菌体安全性和有效性的信息，以推动临床试验的开展，这对于噬菌体疗法成为主流是必要的。在这篇综述中，我们讨论了噬菌体特征描述的基本参数，以及最先进的模型的优缺点，以收集噬菌体治疗安全性和有效性的临床前数据。
