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结合血液透析和螯合聚合物直接提取内源性游离金属阳离子的可行性研究。

Feasibility study and direct extraction of endogenous free metallic cations combining hemodialysis and chelating polymer.

机构信息

MexBrain, 13 Avenue Albert Einstein, 69100, Villeurbanne, France.

ILM, Institut Lumière Matière, UMR 5306, CNRS, Université Lyon1, Université de Lyon, Villeurbanne Cedex, France.

出版信息

Sci Rep. 2021 Oct 7;11(1):19948. doi: 10.1038/s41598-021-99462-y.

DOI:10.1038/s41598-021-99462-y
PMID:34620952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8497614/
Abstract

In this article, we report the conception and the use of dialysis-based medical device for the extraction of metals. The medical device is obtained by addition in the dialysate of a functionalized chitosan that can chelate endogenous metals like iron or copper. This water-soluble functionalized chitosan is obtained after controlled reacetylation and grafting of DOTAGA. Due to the high mass of chitosan, the polymer cannot cross through the membrane and the metals are trapped in the dialysate during hemodialysis. Copper extraction has been evaluated in vitro using an hemodialysis protocol. Feasibility study has been performed on healthy sheep showing no acute toxicity througout the entire dialysis procedure and first insights of metallic extraction even on healthy animals.

摘要

在本文中，我们报告了基于透析的医疗器械的构思和使用，用于提取金属。该医疗器械是通过在透析液中添加一种功能化壳聚糖获得的，该壳聚糖可以螯合内源性金属，如铁或铜。这种水溶性功能化壳聚糖是在 DOTAGA 的受控再乙酰化和接枝后获得的。由于壳聚糖的质量很高，聚合物不能穿过膜，并且在血液透析过程中金属被截留在透析液中。已经使用血液透析方案在体外评估了铜的提取。在健康绵羊上进行了可行性研究，整个透析过程中未表现出急性毒性，并且即使在健康动物上也首次观察到了金属提取的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/4c40863a55aa/41598_2021_99462_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/f9ff6db66c91/41598_2021_99462_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/3325d6a3892c/41598_2021_99462_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/927817a09f19/41598_2021_99462_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/e17954e26f62/41598_2021_99462_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/4bc557c5a506/41598_2021_99462_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/4c40863a55aa/41598_2021_99462_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/f9ff6db66c91/41598_2021_99462_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/3325d6a3892c/41598_2021_99462_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/927817a09f19/41598_2021_99462_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/e17954e26f62/41598_2021_99462_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/4bc557c5a506/41598_2021_99462_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5e5/8497614/4c40863a55aa/41598_2021_99462_Fig6_HTML.jpg

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