Roy Anitha, Sleeba Aneymol Varikalam, Joy Rini, Rajagopal Ponnulakshmi
Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Department of Microbiology, St. Xavier's College for Women, Aluva, Kerala-683101, India.
Bioinformation. 2020 Sep 30;16(9):719-724. doi: 10.6026/97320630016719. eCollection 2020.
Staphylococcus aureus has been recognized as an important human pathogen for more than 100 years. DNA ligase is the main protein responsible for the replication of S. aureus. DNA ligase was selected as successive target to control the replication mechanism. The antibacterial activity of polysaccharide is known. Therefore, it is of interest to study the activity of Polysaccharide analogues against DNA ligase in S. aureus using molecular docking analysis. We report ten analogues using scoring parameters with best two analogues as potential drug candidate for the combat of S. aureus infection.
100多年来，金黄色葡萄球菌一直被认为是一种重要的人类病原体。DNA连接酶是负责金黄色葡萄球菌复制的主要蛋白质。DNA连接酶被选为控制复制机制的连续靶点。多糖的抗菌活性是已知的。因此，利用分子对接分析研究多糖类似物对金黄色葡萄球菌中DNA连接酶的活性是很有意义的。我们报告了10种类似物，使用评分参数，其中两种最佳类似物作为对抗金黄色葡萄球菌感染的潜在候选药物。
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