Shepp M, Necheles T F, Banks H H, Oh W H, Zimbler S
Cancer Treat Rep. 1978 Feb;62(2):295-6.
Six patients with osteosarcoma and no evidence of metastases received postoperative adjuvant chemotherapy with high-dose cyclophosphamide (25 mg/kg iv every other day for five doses). Three of these patients are alive without evidence of disease at 2 1/2, 3, and 5 years following diagnosis. The regimen was tolerable in terms of toxicity. Cyclophosphamide in high doses may be effective adjuvant therapy in some patients with osteosarcoma.
6例骨肉瘤患者且无转移证据，术后接受大剂量环磷酰胺辅助化疗（25mg/kg静脉注射，隔日1次，共5剂）。其中3例患者在诊断后2.5年、3年和5年时存活且无疾病证据。该方案在毒性方面是可耐受的。大剂量环磷酰胺可能对某些骨肉瘤患者是有效的辅助治疗。
