Rissing J P, Buxton T B
J Infect Dis. 1986 Oct;154(4):627-30. doi: 10.1093/infdis/154.4.627.
Infections with Staphylococcus aureus were induced in rat tibiae without sclerosing agents. Animals received ibuprofen or 0.9% NaCl. Both ibuprofen-treated and control animals developed a progressively more-destructive disease over 12 days. Gross tibial pathology was significantly reduced in animals receiving ibuprofen for both six and 12 days postinfection. Radiographic evidence of osteomyelitis was attenuated at 12 days. Geometric mean counts of S. aureus were, however, not significantly changed by ibuprofen treatment. Mean levels of prostaglandin E2 (PGE2) were highest in untreated controls. Ibuprofen treatment of infected animals was associated with a much-reduced mean value of PGE2. Ibuprofen-treated infected tibiae disclosed less PGE2 than did either ibuprofen- or NaCl-treated uninfected tibiae.
在未使用硬化剂的情况下，在大鼠胫骨中诱发金黄色葡萄球菌感染。动物接受布洛芬或0.9%氯化钠。布洛芬治疗组和对照组动物在12天内均出现了破坏性越来越大的疾病。在感染后6天和12天接受布洛芬治疗的动物中，胫骨大体病理学显著减轻。12天时骨髓炎的影像学证据减弱。然而，布洛芬治疗并未显著改变金黄色葡萄球菌的几何平均计数。未治疗的对照组中前列腺素E2（PGE2）的平均水平最高。对感染动物进行布洛芬治疗后，PGE2的平均值大幅降低。与布洛芬或氯化钠治疗的未感染胫骨相比，布洛芬治疗的感染胫骨中PGE2含量更低。
