Merle-Melet M, Bresler L, Lokiec F, Dopff C, Boissel P, Dureux J B
Infectious Diseases Department, Centre Hospitalier Universitaire Nancy-Brabois, Vandoeuvre les Nancy, France.
Antimicrob Agents Chemother. 1992 Oct;36(10):2331-3. doi: 10.1128/AAC.36.10.2331.
The effects of diclofenac, a nonsteroidal antiinflammatory drug, on the biliary and urinary excretion of ceftriaxone were evaluated in subjects with a T drain in the common bile duct. The kinetic study was carried out on the sixth postoperative day of treatment with ceftriaxone alone (2 g intravenously; group 1) or ceftriaxone combined with diclofenac (50 mg every 12 h orally from postoperative days 3 to 6; group 2). A significant increase in the elimination half-life of ceftriaxone was observed in group 2 patients. Diclofenac caused a significant rise in ceftriaxone biliary excretion. This increase was not sufficient to balance the significant deficit of urinary excretion of ceftriaxone.
在胆总管置有T形引流管的受试者中，评估了非甾体抗炎药双氯芬酸对头孢曲松胆汁和尿液排泄的影响。动力学研究在单独使用头孢曲松治疗（静脉注射2g；第1组）或头孢曲松联合双氯芬酸（术后第3至6天每12小时口服50mg；第2组）的术后第6天进行。在第2组患者中观察到头孢曲松的消除半衰期显著延长。双氯芬酸导致头孢曲松胆汁排泄显著增加。这种增加不足以平衡头孢曲松尿液排泄的显著减少。
