Little Rory F, Hertweck Christian
Leibniz Institute for Natural Product Research and Infection Biology, HKI, Germany.
Nat Prod Rep. 2022 Jan 26;39(1):163-205. doi: 10.1039/d1np00035g.
Review covering up to mid-2021The structure of polyketide and non-ribosomal peptide natural products is strongly influenced by how they are released from their biosynthetic enzymes. As such, Nature has evolved a diverse range of release mechanisms, leading to the formation of bioactive chemical scaffolds such as lactones, lactams, diketopiperazines, and tetronates. Here, we review the enzymes and mechanisms used for chain release in polyketide and non-ribosomal peptide biosynthesis, how these mechanisms affect natural product structure, and how they could be utilised to introduce structural diversity into the products of engineered biosynthetic pathways.
截至2021年年中的综述聚酮化合物和非核糖体肽天然产物的结构受到其从生物合成酶中释放方式的强烈影响。因此，自然界进化出了多种释放机制，导致形成了内酯、内酰胺、二酮哌嗪和特窗酸等生物活性化学支架。在这里，我们综述了聚酮化合物和非核糖体肽生物合成中用于链释放的酶和机制、这些机制如何影响天然产物结构，以及如何利用它们在工程生物合成途径的产物中引入结构多样性。
