提高 minimap2 比对准确性的新策略。
New strategies to improve minimap2 alignment accuracy.
机构信息
Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Bioinformatics. 2021 Dec 7;37(23):4572-4574. doi: 10.1093/bioinformatics/btab705.
Abstract
SUMMARY
We present several recent improvements to minimap2, a versatile pairwise aligner for nucleotide sequences. Now minimap2 v2.22 can more accurately map long reads to highly repetitive regions and align through insertions or deletions up to 100 kb by default, addressing major weakness in minimap2 v2.18 or earlier.
AVAILABILITY AND IMPLEMENTATION
摘要
摘要
我们介绍了 minimap2 的几个最新改进，minimap2 是一种用于核苷酸序列的通用比对工具。现在，minimap2 v2.22 可以更准确地将长读段映射到高度重复的区域，并通过默认的 100kb 以内的插入或缺失来进行对齐，从而解决了 minimap2 v2.18 或更早版本中的主要弱点。
可用性和实现
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