Aix Marseille Univ, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France.
Biochem Soc Trans. 2021 Nov 1;49(5):2307-2317. doi: 10.1042/BST20210399.
The simple notion 'infection causes an immune response' is being progressively refined as it becomes clear that immune mechanisms cannot be understood in isolation, but need to be considered in a more global context with other cellular and physiological processes. In part, this reflects the deployment by pathogens of virulence factors that target diverse cellular processes, such as translation or mitochondrial respiration, often with great molecular specificity. It also reflects molecular cross-talk between a broad range of host signalling pathways. Studies with the model animal C. elegans have uncovered a range of examples wherein innate immune responses are intimately connected with different homeostatic mechanisms, and can influence reproduction, ageing and neurodegeneration, as well as various other aspects of its biology. Here we provide a short overview of a number of such connections, highlighting recent discoveries that further the construction of a fully integrated view of innate immunity.
简单的概念“感染引起免疫反应”正在逐渐得到完善，因为越来越明显的是，免疫机制不能孤立地理解，而需要在更全局的背景下，与其他细胞和生理过程一起考虑。部分原因是病原体利用了针对多种细胞过程的毒力因子，例如翻译或线粒体呼吸，通常具有很高的分子特异性。这也反映了宿主信号通路之间的广泛分子串扰。使用模式动物秀丽隐杆线虫的研究揭示了一系列例子，其中先天免疫反应与不同的体内平衡机制密切相关，并可以影响生殖、衰老和神经退行性变，以及其生物学的许多其他方面。在这里，我们简要概述了其中的一些联系，重点介绍了进一步构建先天免疫综合观点的最新发现。
