Guan Tianpei, Cheng Ming, Zeng Lisi, Chen Xiaoya, Xie Yuan, Lei Ziying, Ruan Qiang, Wang Jin, Cui Shuzhong, Sun Yao, Li Haibing
Department 2 of Gastroentestinal Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, P. R. China.
Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China.
ACS Appl Mater Interfaces. 2021 Oct 20;13(41):49137-49145. doi: 10.1021/acsami.1c12061. Epub 2021 Oct 8.
Bioinspired artificial nanochannels for molecular and ionic transport have extensive applications. However, it is still a huge challenge to achieve an intelligent transport system with high selectivity/efficiency and controllability. Inspired by glutathione transport across the plasma membrane via redox regulation, we herein designed and fabricated a redox-reactive artificial nanochannel based on the host-guest chemical strategy. The nanochannel platform achieved high selectivity/efficiency for the identification and transmission of glutathione in the confined space. In addition, this nanochannel can switch between the ON and OFF states through the redox reaction. This redox-regulated system can provide a potential application for detection/binding of biological analytes and redox-controlled drug release.
用于分子和离子传输的仿生人工纳米通道具有广泛的应用。然而，要实现一个具有高选择性/效率和可控性的智能传输系统仍然是一个巨大的挑战。受谷胱甘肽通过氧化还原调节穿过质膜的启发，我们在此基于主客体化学策略设计并制造了一种氧化还原反应性人工纳米通道。该纳米通道平台在受限空间内对谷胱甘肽的识别和传输实现了高选择性/效率。此外，这种纳米通道可以通过氧化还原反应在开和关状态之间切换。这种氧化还原调节系统可为生物分析物的检测/结合以及氧化还原控制的药物释放提供潜在应用。
