Fagron BV, Rotterdam, The Netherlands.
Int J Pharm Compd. 2021 Sep-Oct;25(5):422-426.
Transdermal products are intended to be applied topically but to promote the biological effects systemically, while transmucosal products have the same final effect but are to be applied on mucosa (for example, vaginal mucosa). The extension and velocity in which absorption occurs vary depending on the vehicle used, the active pharmaceutical ingredient and a broad range of other factors related to the formulation, patient, and environmental characteristics. Ready-to-use vehicles, such as Pentravan, with proven penetration efficacy for various active pharmaceutical ingredients, are paramount. Pentravan, specially developed for compounding pharmacies, has been extensively studied. To date, most studies have focused on endocrinology (e.g., sexual hormones), anti-aging strategies, and gynecology (endometriosis and related conditions). In this work, we have determined the compatibility of Pentravan and three active pharmaceutical ingredients: gestrinone, a steroidal substance for vaginal use (endometriosis), and nimesulide and piroxicam, two nonsteroidal anti-inflammatory drugs used both for topical and vaginal application. This article shows an excellent beyond-use date of 180 days when stored at room temperature, which renders it suitable for daily practice.
透皮产品旨在局部应用，但促进全身的生物学效应，而粘膜产品具有相同的最终效果，但应用于粘膜（例如，阴道粘膜）。吸收发生的扩展和速度取决于所使用的载体、活性药物成分以及与制剂、患者和环境特征相关的广泛其他因素。已经证明对各种活性药物成分具有渗透功效的即用型载体（如 Pentravan）至关重要。Pentravan 是专为制剂药房开发的，已经进行了广泛的研究。迄今为止，大多数研究都集中在内分泌学（例如，性激素）、抗衰老策略和妇科（子宫内膜异位症和相关病症）。在这项工作中，我们已经确定了 Pentravan 和三种活性药物成分的相容性：孕三烯酮，一种用于阴道的甾体物质（子宫内膜异位症），以及尼美舒利和吡罗昔康，两种非甾体抗炎药，用于局部和阴道应用。本文显示在室温下储存时，超过使用期限为 180 天，这使其适合日常使用。
