局部用尼美舒利凝胶在多种实验模型中的抗炎活性
Anti-inflammatory activity of topical nimesulide gel in various experimental models.
作者信息
Gupta S K, Prakash J, Awor L, Joshi S, Velpandian T, Sengupta S
机构信息
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
出版信息
Inflamm Res. 1996 Dec;45(12):590-2. doi: 10.1007/BF02312040.
OBJECTIVE AND DESIGN
The anti-inflammatory activity of topically applied nimesulide gel was compared in different experimental models with that of diclofenac and piroxicam gels.
MATERIAL
Wistar albino rats of either sex were used.
TREATMENT
In acute models, 50 mg of nimesulide or diclofenac were applied to right hind paws 1 h (carrageenan) or immediately before (formalin) irritant injection (sub-plantar). In adjuvant arthritis, 50 mg of nimesulide, diclofenac or piroxicam were applied daily to injected paws for 14 days.
METHODS
Paw volume was measured by plethysmograph. Statistical significance was tested with Student's t-test.
RESULTS
In the carrageenan paw odema, topical nimesulide gel exhibited similar anti-inflammatory activity to diclofenac gel, and was more effective than diclofenac gel in formalin-paw odema. In both acute (18 h) and chronic (14 d) phases of adjuvant arthritis, nimesulide gel was more effective than diclofenac or piroxicam gels.
CONCLUSION
Topical nimesulide gel possesses higher anti-inflammatory activity than that of diclofenac or piroxicam gels.
目的与设计
将局部应用的尼美舒利凝胶在不同实验模型中的抗炎活性与双氯芬酸凝胶和吡罗昔康凝胶进行比较。
材料
使用了不同性别的Wistar白化大鼠。
处理
在急性模型中，在注射（足底皮下）刺激性物质前1小时（角叉菜胶）或立即（福尔马林）将50毫克尼美舒利或双氯芬酸应用于右后爪。在佐剂性关节炎中，每天将50毫克尼美舒利、双氯芬酸或吡罗昔康应用于注射爪，持续14天。
方法
通过体积描记器测量爪体积。采用学生t检验进行统计学显著性检验。
结果
在角叉菜胶致爪肿胀中，局部应用尼美舒利凝胶表现出与双氯芬酸凝胶相似的抗炎活性，且在福尔马林致爪肿胀中比双氯芬酸凝胶更有效。在佐剂性关节炎的急性（18小时）和慢性（14天）阶段，尼美舒利凝胶均比双氯芬酸或吡罗昔康凝胶更有效。
结论
局部应用的尼美舒利凝胶具有比双氯芬酸或吡罗昔康凝胶更高的抗炎活性。
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