Department of General Thoracic Surgery, Kohka Public Hospital, Matsuo, Minakuchi, Kohka, Shiga, Japan.
Department of General Thoracic Surgery, Kohka Public Hospital, Matsuo, Minakuchi, Kohka, Shiga, Japan.
Ann Thorac Surg. 2022 Jul;114(1):e47-e50. doi: 10.1016/j.athoracsur.2021.08.070. Epub 2021 Oct 6.
Thyroid transcription factor-1 (TTF-1) has been widely used as a marker of primary lung cancer. However, there have been few reports on TTF-1 expression in thymomas. We here report the case of an asymptomatic 63-year-old man who presented with a right upper lung nodule and cystic mid-mediastinal tumor. The right upper lobe of the lung and the mediastinal tumor were resected. Histological examination of the operative specimen revealed TTF-1-positive type B2 thymoma and invasive pulmonary adenocarcinoma. Although rare, thymoma should be included in the different diagnosis of TTF-1-positive tumors.
甲状腺转录因子-1（TTF-1）已被广泛用作原发性肺癌的标志物。然而，关于胸腺瘤中 TTF-1 表达的报道很少。我们在此报告一例无症状的 63 岁男性，其表现为右上肺结节和囊性中纵隔肿瘤。切除右肺上叶和纵隔肿瘤。手术标本的组织学检查显示 TTF-1 阳性 B2 型胸腺瘤和侵袭性肺腺癌。尽管罕见，但胸腺瘤应包括在 TTF-1 阳性肿瘤的鉴别诊断中。
