Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Neurology, MS Center and Neuro-ophthalmology Expertise Center, Amsterdam Neuroscience, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Ophthalmology, Neuro-ophthalmology Expertise Center, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Neurology, MS Center and Neuro-ophthalmology Expertise Center, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Neuroimage Clin. 2021;32:102848. doi: 10.1016/j.nicl.2021.102848. Epub 2021 Oct 4.
Impaired eye movements in multiple sclerosis (MS) are common and could represent a non-invasive and accurate measure of (dys)functioning of interconnected areas within the complex brain network. The aim of this study was to test whether altered saccadic eye movements are related to changes in functional connectivity (FC) in patients with MS.
Cross-sectional eye movement (pro-saccades and anti-saccades) and magnetoencephalography (MEG) data from the Amsterdam MS cohort were included from 176 MS patients and 33 healthy controls. FC was calculated between all regions of the Brainnetome atlas in six conventional frequency bands. Cognitive function and disability were evaluated by previously validated measures. The relationships between saccadic parameters and both FC and clinical scores in MS patients were analysed using multivariate linear regression models.
In MS pro- and anti-saccades were abnormal compared to healthy controls A relationship of saccadic eye movements was found with FC of the oculomotor network, which was stronger for regional than global FC. In general, abnormal eye movements were related to higher delta and theta FC but lower beta FC. Strongest associations were found for pro-saccadic latency and FC of the precuneus (beta band β = -0.23, p = .006), peak velocity and FC of the parietal eye field (theta band β = -0.25, p = .005) and gain and FC of the inferior frontal eye field (theta band β = -0.25, p = .003). Pro-saccadic latency was also strongly associated with disability scores and cognitive dysfunction.
Impaired saccadic eye movements were related to functional connectivity of the oculomotor network and clinical performance in MS. This study also showed that, in addition to global network connectivity, studying regional changes in MEG studies could yield stronger correlations.
多发性硬化症（MS）患者的眼球运动障碍很常见，这可能代表着大脑网络中相互连接的区域（功能）出现障碍的一种非侵入性且准确的测量方法。本研究旨在测试眼球运动（扫视和反向扫视）是否与 MS 患者的功能连接（FC）变化有关。
纳入了阿姆斯特丹 MS 队列的 176 名 MS 患者和 33 名健康对照者的横断面眼动（前向扫视和反向扫视）和脑磁图（MEG）数据。在六个常规频带中，计算了 Brainnetome 图谱中所有区域之间的 FC。认知功能和残疾通过先前验证的测量方法进行评估。使用多元线性回归模型分析 MS 患者的扫视参数与 FC 和临床评分之间的关系。
MS 患者的前向和反向扫视与健康对照组相比均异常。扫视眼动与眼球运动网络的 FC 有关，区域 FC 比全局 FC 的关系更强。一般来说，异常的眼球运动与更高的 delta 和 theta FC 有关，但与更低的 beta FC 有关。前向扫视潜伏期与楔前叶 FC（beta 波段β=-0.23，p=0.006）、峰值速度与顶叶眼区 FC（theta 波段β=-0.25，p=0.005）以及增益与下额叶眼区 FC（theta 波段β=-0.25，p=0.003）的相关性最强。前向扫视潜伏期与残疾评分和认知功能障碍也有很强的相关性。
扫视眼动障碍与 MS 患者的眼球运动网络功能和临床表现有关。本研究还表明，除了全局网络连接性外，在 MEG 研究中研究局部变化可以产生更强的相关性。
