Sudo Yusuke, Kamashita Rio, Takamura Tsunehiko, Hamatani Sayo, Numata Noriko, Matsumoto Koji, Sato Yasuhiro, Hamamoto Yumi, Shoji Tomotaka, Muratsubaki Tomohiko, Sugiura Motoaki, Fukudo Shin, Kawabata Michiko, Sunada Momo, Noda Tomomi, Tose Keima, Isobe Masanori, Kodama Naoki, Kakeda Shingo, Takahashi Masatoshi, Adachi Hiroaki, Takakura Shu, Gondo Motoharu, Yoshihara Kazufumi, Moriguchi Yoshiya, Shimizu Eiji, Sekiguchi Atsushi, Hirano Yoshiyuki
Research Center for Child Mental Development Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Department of Cognitive Behavioral Physiology, Chiba University, Chiba, Japan.
Sci Rep. 2025 May 31;15(1):19118. doi: 10.1038/s41598-025-03641-0.
Although changes in insular function have been thought to play a central role in the pathophysiology of anorexia nervosa (AN), due to factors such as insufficient sample size, there have been no studies examining changes in resting-state functional connectivity (rsFC) between insula and whole brain in AN, based on functional localization of insula. Here, we subdivided insula into 6 regions per side based on functional localization and reanalyzed previously published functional magnetic resonance imaging data from 114 female patients with AN and 135 female healthy controls (HC). We calculated the rsFCs between ROIs and compared the results between groups, with the 12 insular regions serving as seed ROIs and 142 regions of the whole brain as target ROIs. Compared to HC, AN patients had a increased rsFC between dorsal anterior insula (daIC) and amygdala, and a decreased rsFC between posterior division of dorsal middle insula (pdmIC) and opercular cortex (false discovery rate [FDR] corrected p-value < 0.05 with analysis-level correction, which means that FDR correction was applied to all seed ROIs and all target ROI combinations). These rsFC changes may be the neurological basis for AN symptoms, such as hypersensitivity to negative stimuli, taste disorder, and enhanced taste aversion learning.
尽管岛叶功能变化被认为在神经性厌食症（AN）的病理生理学中起核心作用，但由于样本量不足等因素，基于岛叶的功能定位，尚无研究考察AN患者岛叶与全脑之间静息态功能连接（rsFC）的变化。在此，我们根据功能定位将岛叶每侧细分为6个区域，并重新分析了先前发表的来自114名女性AN患者和135名女性健康对照（HC）的功能磁共振成像数据。我们计算了感兴趣区域（ROI）之间的rsFC，并比较了组间结果，将12个岛叶区域作为种子ROI，将全脑的142个区域作为目标ROI。与HC相比，AN患者背侧前岛叶（daIC）与杏仁核之间的rsFC增加，背侧中岛叶后部分（pdmIC）与岛盖皮质之间的rsFC减少（经分析水平校正的错误发现率[FDR]校正p值<0.05，这意味着对所有种子ROI和所有目标ROI组合都应用了FDR校正）。这些rsFC变化可能是AN症状的神经学基础，如对负面刺激的超敏反应、味觉障碍和增强的味觉厌恶学习。
