Guo M, Xu J
School of Public Health, Zunyi Medical University, Zunyi 563000, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 Sep 20;39(9):717-720. doi: 10.3760/cma.j.cn121094-20201025-00510.
Endocrine disrupting chemicals (EDCs) are a kind of exogenous chemicals widely existing in the environment, which cause serious harm to the environment and human health. At present, the impact of this type of substance on the thyroid has attracted much attention.This review summarized the effects of EDCs on thyroid hormones, and phosphatidylinositol 3-kinase (PI3K) /protein kinase B (Akt) /mammalian target of rapamycin (mTOR) (PI3K/Akt/mTOR) signaling pathway and its role in thyroid diseases, and explore the role of PI3K/Akt/mTOR signaling pathway in EDCs-induced apoptosis and autophagy of thyroid follicular epithelial cells.This paper could provide further understandings for thyroid diseases induced by the autophagy and apoptosis of thyroid follicular epithelial cells.
内分泌干扰化学物（EDCs）是一类广泛存在于环境中的外源性化学物，对环境和人类健康造成严重危害。目前，这类物质对甲状腺的影响备受关注。本综述总结了EDCs对甲状腺激素、磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（Akt）/雷帕霉素哺乳动物靶蛋白（mTOR）（PI3K/Akt/mTOR）信号通路的影响及其在甲状腺疾病中的作用，并探讨PI3K/Akt/mTOR信号通路在EDCs诱导甲状腺滤泡上皮细胞凋亡和自噬中的作用。本文可为甲状腺滤泡上皮细胞自噬和凋亡诱导的甲状腺疾病提供进一步的认识。
