Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, P. R. China.
Henan University of Animal Husbandry and Economy, Zhengzhou, 450001, P. R. China.
Chemistry. 2021 Dec 15;27(70):17565-17569. doi: 10.1002/chem.202103219. Epub 2021 Oct 22.
Tf O mediated intermolecular / intramolecular [2+2+2] cycloaddition between alkynes and nitriles has been developed for efficient construction of polysubstituted pyrimidines and bicyclopyrimidines. In presence of Tf O, aza-allene species were generated in situ through nitrile activation and subsequently participated in the [2+2+2] cycloaddition, which was fully supported by deuteration experiments. The reaction had good substrate extensibility with moderate to excellent yield including trimethylsilylalkynes. The method was utilized as a synthetic tool in the preparation of a luminescent metal complex.
TfO 介导的炔烃和腈之间的分子间/分子内 [2+2+2]环加成已被开发用于高效构建多取代嘧啶和双环嘧啶。在 TfO 的存在下，通过腈的活化原位生成氮杂丙二烯物种，随后参与 [2+2+2]环加成，这完全得到氘代实验的支持。该反应具有良好的底物扩展性，包括三甲基硅基炔烃，产率中等至优秀。该方法被用作合成工具，用于制备发光金属配合物。
